P53 (fosfo Ser15) Antilichaam

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

7157

P04637

NP_000537.3

Human

P53 (Phospho-Ser15) antibody was raised against a peptide sequence around phosphorylation site of serine 15 (P-L-S (p) -Q-E) derived from Human p53.

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

53 kDa

This antibody detects endogenous level of p53 only whenphosphorylated at serine15.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

TP53

Tumor protein p53

Homo sapiens

Lin T, et al. (2005) Nat Cell Biol; 7 (2) : 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24 (23) : 10366-80. Li J, et al. (2004) J Biol Chem; 279 (40) : 41275-9. Wang J, et al. (2004) J Biol Chem; 279 (38) : 39584-92.

P53, BCC7, LFS1, TRP53, MEK6, MKK6, PRKMK6, SKK3, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13, TP53

WB, IHC, IF

120407068

Liquid