P53 (fosfo Thr387) Antilichaam

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

7157

P04637

NP_000537.3

Human

P53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p) -E-G) derived from Human p53.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

43 kDa

IgG

The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.

TP53

Tumor protein p53

Homo sapiens

Zakut-Houri R., EMBO J. 4:1251-1255 (1985) .

Lamb P., Mol. Cell. Biol. 6:1379-1385 (1986) .

Harlow E., Mol. Cell. Biol. 5:1601-1610 (1985) .

TP53, tumor protein p53, Tumor suppressor p53

IHC

120407068

Liquid