P56Dok 2 (fosfo Tyr299) Antilichaam

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation

9046

O60496

NP_003965.2

Human

P56Dok-2 (Phospho-Tyr299) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 299 (G-E-Y (p) -A-V) derived from Human p56Dok-2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

56 kDa

This antibody detects endogenous level of p56Dok-2 only when phosphorylated at tyrosine 299.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

DOK2

Docking protein 2, 56kDa

Homo sapiens

Feng Cong, et, al. (1999) Mol. Cell. Biol ; 19: 8314 - 8325. Serge Lemay, et, al. (2000) Mol. Cell. Biol ; 20: 2743 - 2754. Ute Schaeper, et, al. (2000) J. Cell Biol ; 149: 1419. Miyuki Honma, et, al. (2006) Genes Cells; 11: 143 - 151.

P56DOK, p56dok-2, CPP32, DOK2

WB, IHC, IF

41406050

Liquid