P62Dok (Ab 362) Antilichaam

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

1796

Q99704

NP_001372.1

Human, Mouse, Rat

P62Dok (Ab-362) antibody was raised against a peptide sequence around aa.360~364 (P-I-Y-D-E) derived from Human p62Dok.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

62 kDa

This antibody detects endogenous level of total p62Dok protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

DOK1

Docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Homo sapiens

Zhou Songyang, et, al. (2001) J. Biol. Chem ; 276: 2459 - 2465. Jean-Guy Nemorin, et, al. (2000) J. Biol. Chem ; 275: 14590. Yuji Yamanashi, et, al. (2000) Genes & Dev ; 14: 11. Ibuki Kato, et, al. (2002) J. Immunol ; 168: 629.

P62DOK, T3E, DOK1

WB, IHC

4503357

Liquid