P70 S6 Kinase (fosfo Ser424) Antilichaam

Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.

6198

P23443

NP_003152.1

Human, Mouse, Rat

P70 S6 Kinase (Phospho-Ser424) antibody was raised against a peptide sequence around phosphorylation site of serine 424 (P-V-S (p) -P-V) derived from Human p70 S6 Kinase.

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

70, 85 kDa

This antibody detects endogenous level of p70 S6 Kinase only when phosphorylated at serine 424.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

RPS6KB1

Ribosomal protein S6 kinase, 70kDa, polypeptide 1

Homo sapiens

Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24) : 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484–97

S6K, PS6K, S6K1, STK14A, p70-S6K, p70S6KA, p70-alpha, S6K-beta-1, p70 (S6K) -alpha, HCP, PTP1C, KS6B1, P70-S6K, RPS6KB1, S6K

WB, IHC, IF

4506737

Liquid