P70 S6 Kinse (Ab 389) Antilichaam

Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.

6198

P23443

NP_003152.1

Human, Mouse, Rat

P70 S6 Kinase (Ab-389) antibody was raised against a peptide sequence around aa.387~391 (G-F-T-Y-V) derived from Human p70 S6 Kinase.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

70, 85 kDa

This antibody detects endogenous level of total p70 S6 Kinase protein.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

RPS6KB1

Ribosomal protein S6 kinase, 70kDa, polypeptide 1

Homo sapiens

Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24) : 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484–97

S6K, PS6K, S6K1, STK14A, p70-S6K, p70S6KA, p70-alpha, S6K-beta-1, p70 (S6K) -alpha, KS6B1, P70-S6K, RPS6KB1, S6K

WB, IF

4506737

Liquid