P90 RSK (fosfo Thr573) Antilichaam

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.

6195

Q15418

NP_002944.2

Human, Mouse, Rat

P90 RSK (phospho Thr573) antibody was raised against a peptide sequence around phosphorylation site of threonine 573 (L-M-T (p) -P-C) derived from Human p90 RSK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

95 kDa

IgG

The antibody detects endogenous levels of P90RSK only when phosphorylated at threonine 573.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

RPS6KA1

Ribosomal protein S6 kinase, 90kDa, polypeptide 1

Homo sapiens

Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206.

Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048.

Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835.

KS6A1, p90RSK1, RSK1, RPS6KA1

WB, IHC

292457

Liquid