P95 / NBS1 (fosfo Ser343) Antilichaam

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

4683

O60934

NP_002476.2

Human, Mouse, Rat

P95/NBS1 (Phospho-Ser343) antibody was raised against a peptide sequence around phosphorylation site of serine 343 (S-L-S (p) -Q-G) derived from Human p95/NBS1.

Unconjugated

Primary Antibodies

Phospho-Specific, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

95 kDa

This antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.

Western Blot: 1:500~1:1000

NBN

Nibrin

Homo sapiens

Hsu HL, et al (2005) Oncogene; 24 (31) : 4956-64. Falck J, et al. (2005) Nature; 434 (7033) : 605-11. Buscemi G, et al. (2004) Oncogene; 23 (46) : 7691-700. Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101 (33) : 12130-5.

ATV, NBS, P95, NBS1, AT-V1, AT-V2, TCF5, PP9092

WB

33356172

Liquid