P95 NBS1 (NBN) (NM 002485) Humaan Recombinant eiwit

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human nibrin (NBN), Pro461-Arg754, with N-terminal His tag, expressed in E. coli, 50ug

AT-V1; AT-V2; ATV; NBS; NBS1; P95

4683

O60934

NM_002485

8q21.3

E. coli

N-His

Homologous recombination

Homologous recombination

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome

34 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

NBN

Human

NP_002476

https://www.ncbi.nlm.nih.gov/gene/4683

https://www.uniprot.org/uniprot/O60934

https://www.ncbi.nlm.nih.gov/nuccore/NM_002485

https://www.ncbi.nlm.nih.gov/nuccore/NP_002476