PABPN1 Recombinant antilichaam [6C3] (OACA12590)

Poly (A) binding protein nuclear 1

Nuclear poly (A) -binding protein 1; OPMD; PAB2; PABII; PABP2; PABP-2; poly (A) binding protein 2; poly (A) binding protein II; Poly (A) -binding protein II; Polyadenylate-binding nuclear protein 1; polyadenylate-binding protein 2.

8106

Human

A synthesized peptide derived from human PABPN1

Unconjugated

Recombinant Monoclonal Antibody

Affinity Purified

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly (A) tail of 200-250 nt to the upstream cleavage product (By similarity) . Stimulates poly (A) polymerase (PAPOLA) conferring processivity on the poly (A) tail elongation reaction and controls also the poly (A) tail length (By similarity) . Increases the affinity of poly (A) polymerase for RNA (By similarity) . Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506) . Binds to poly (A) and to poly (G) with high affinity (By similarity) . May protect the poly (A) tail from degradation (By similarity) . Subunit of the trimeric poly (A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly (A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484) .

Liquid

-20°C or -80°C

PABPN1

Polyadenylate-binding protein 2

PABPN1