Paclitaxel-13C6

Paclitaxel-13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy[1][2].

12352005

ADC Payload; Apoptosis; Autophagy; Isotope-Labeled Compounds; Microtubule/Tubulin

Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Others

Cancer-programmed cell death

Cancer

O=C([C@]1([C@@H]([C@@H]([C@@]2(C[C@@H](C(C)=C3C2(C)C)OC([C@H]([C@@H](C4=CC=CC=C4)NC(C5=CC=CC=C5)=O)O)=O)O)OC([13C]6=[13C]([13C]([H])=[13C]([13C]([H])=[13C]6[H])[H])[H])=O)[C@]7(OC(C)=O)CO[C@@H]7C[C@@H]1O)C)[C@@H]3OC(C)=O

C41 13C6H51NO14

859.86

[1]Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28 (6) :2163-9.|[2]Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24 (1) :27-36.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W768912/

Isotope-Labeled Compounds

No Development Reported