PACS1 Antilichaam

The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2) . Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome (3) . PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance (4) .

55690

Q6VY07

NP_060496

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Infectious Disease, Stem Cell

PACS1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1478 - Rat Bladder Tissue Lysate

1 mg/mL

PACS1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PACS1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PACS1 antibody is human, mouse and rat reactive. Multiple isoforms of PACS1 are known to exist. PACS1 antibody is predicted to not cross-react with PACS2.

PACS1

Phosphofurin acidic cluster sorting protein 1

Homo sapiens

Wan L, Molloy SS, Thomas L, et al. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell 1998; 94:205-16.

Kottgen M, Benzing T, Simmen T, et al. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. 2005; 24:705-16.

Schuurs-Hoeijmakers JH, Oh EC, Vissers LE, et al. Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome. Am. J. Hum. Genet. 2012; 91:1122-7.

Dikeakos JD, Thomas L, Kwon G, et al. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS2 on endosomes to down-regulate MHC-I. Mol. Biol. Cell 2012; 23:2184-97.

Phosphofurin acidic cluster sorting protein 1, PACS-1, MRD17

ELISA, WB, IHC-P, IF

30089916

Liquid