PACS2 Antilichaam

PACS2 (phosphofurin acidic cluster sorting protein-2), PACS1L, is an 889 amino acid protein that localizes to both the mitochondrion and the lumen of the endoplasmic reticulum (ER) and belongs to the PACS family (1,2) . It is expressed in a broad range of tissues with highest expression in skeletal muscle, brain, heart, testis and pancreas (2, ) . PACS2 interacts with Polycystin-2 and BID and functions as a sorting protein that regulates mitochondria-ER communication and is thought to be involved in ion channel trafficking, specifically direct cluster-containing ion channels to distinct subcellular compartments (3-5) .

23241

Q86VP3

NP_056012

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

PACS2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

PACS2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PACS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PACS2 antibody is human, mouse and rat reactive. At least three isoforms of PACS2 are known to exist; this antibody will detect all three. PACS2 antibody is predicted to not cross-react with PACS1.

PACS2

Phosphofurin acidic cluster sorting protein 2

Homo sapiens

Kottgen M, Benzing T, Simmen T, et al. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. 2005; 24:705-16.

Brasacchio D, Noori T, House C, et al. A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage. Cell Death Differ. 2014; 21:748-60.

Werneburg NW, Bronk SF, Guicciardi ME, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2) . J. Biol. Chem. 2012; 287:24427-37.

You H and Thomas G. A homeostatic switch in PACS-2 links membrane traffic to TRAIL-induced apoptosis. Cell Cycle 2009; 8:2679-80.

Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS1L

ELISA, WB, IHC-P, IF

155029546

Liquid