PAK1 (fosfo Ser199) Antilichaam

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

5058

Q13153

NP_002567.3

Human, Mouse, Rat

PAK1 (phospho Ser199) antibody was raised against a peptide sequence around phosphorylation site of Serine 199 (T-K-S (p) -V-I) derived from Human PAK1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

61 kDa

IgG

The antibody detects endogenous levels of PAK1/2 only when phosphorylated at serine 199.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

PAK1

P21 protein (Cdc42/Rac) -activated kinase 1

Homo sapiens

Brown J.L., Curr. Biol. 6:598-605 (1996) .

Sells M.A., Curr. Biol. 7:202-210 (1997) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

ADRB2, PAK 1, P65-PAK, P68-PAK

WB, IHC

42794769

Liquid