PAK1 / PAC2 / PAC3 (Ab 423 / 402 / 421) Antilichaam

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

5058;5062;5063

Q13153; ; Q13177; ; O75914

NP_001122092.1; NP_002568.2; NP_001121638.1

Human, Mouse, Rat

PAK1/PAK2/PAK3 (Ab-423/402/421) antibody was raised against a peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

61 - 67 (PAK2) 68 - 74 (PAK1/3) kDa

This antibody detects endogenous level of total PAK1/PAK2/PAK3 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

PAK1 PAK2 PAK3

P21 protein (Cdc42/Rac) -activated kinase 1 / p21 protein (Cdc42/Rac) -activated kinase 2 / p21 protein (Cdc42/Rac) -activated kinase 3

Homo sapiens

Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695. Jung JH, et al. (2005) J Biol Chem; 280:40025-40031. Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447.

PAKalpha, CRSBP1, HAR, XLKD1, UNQ230/PRO263, p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK

WB, IHC, IF

190886457 / 32483399 / 189491751

Liquid