PAK2 (fosfo Ser197) Antilichaam

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

5062

Q13177

NP_002568.2

Human, Mouse, Rat

PAK2 (phospho Ser197) antibody was raised against a peptide sequence around phosphorylation site of Serine 197 (T-R-S (p) -V-I) derived from Human PAK2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

58 kDa

IgG

The antibody detects endogenous levels of PAK2 only when phosphorylated at serine 197.

PAK2

P21 protein (Cdc42/Rac) -activated kinase 2

Homo sapiens

Martin G.A., EMBO J. 14:1970-1978 (1995) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

Olsen J.V., Cell 127:635-648 (2006) .

Gamma-PAK, PAK65, PAKI, PAK 2

IHC

32483399

Liquid