Palm11-PrRP31 (TFA)

Palm11-PrRP31 TFA is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 TFA is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 TFA is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 TFA can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction[1].

12352209

Neuropeptide FF Receptor

GPCR/G Protein

Neuroscience-Neuromodulation

Metabolic Disease; Neurological Disease

99.44

DMSO : 2 mg/mL (ultrasonic)

O=C(NCCCC[C@@H](C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC7=CC=CC=C7)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@H](CC8=CNC=N8)NC([C@H](CCCNC(N)=N)NC([C@H](CC9=CNC=N9)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCC)=O.O=C(O)C(F)(F)F.[x]

C181H289N55O46S·xC2HF3O2

4003.64 (free base)

[1]Strnadová V, et al. Search for lipidized PrRP analogs with strong anorexigenic effect: in vitro and in vivo studies[J]. Neuropeptides, 2023, 98: 102319.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10380A/palm11-PrRP31-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported