PALMD Antilichaam

Palmdelphin (PALMD) is a member of the paralemmin families that are lipid-anchored proteins having a role in the cell shape control and cell dynamics (1,2) . While Paralemmin proteins typically anchor to the cytoplasm through via palmytoylation and prenylation, PALMD is found predominantly in the cytosol (3) . PALMD is targeted to the nucleus to induce apoptosis in response to DNA damage (3-5) . Abnormal genetic alterations in PALMD are observed in many malignant tumors (5) .

54873

Q9NP74

NP_060204

Human

Unconjugated

Primary Antibodies

Apoptosis, Cancer

PALMD antibody is affinity chromatography purified via peptide column.

Cat. No. 1310 - Human Bladder Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (93%), Pig: (93%), Mouse: (86%)

PALMD antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PALMD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PALMD antibody is human specific. At least two isoforms are known to exist.

PALMD

Palmdelphin

Homo sapiens

Hultqvist G, Ocampo Daza D, Larhammar D, et al. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One 2012; 7:e41850.

Andreu N, Escarceller M, Feather S, et al. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Gene 2001; 278:33-40.

Hu B, Copeland NG, Gilbert DJ, et al. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Biochem. Biophys. Res. Commun. 2001; 285:1369-76.

Dashzeveg N, Taira N, Lu ZG, et al. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death Dis. 2014; 5:e1221.

Palmdelphin, C1orf11, FLJ20271, PALML, Paralemnin-like protein

ELISA, WB, IHC-P

8923243

Liquid