Palmitoyltetrapeptide-20

Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying[1].

PTP20

12352209

Melanocortin Receptor; Sirtuin

Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Neuronal Signaling

Metabolism-protein/nucleotide metabolism

Metabolic Disease; Inflammation/Immunology

99.67

DMSO : 28.57 mg/mL (adjust pH to 4 with 1 M HCl)

CCCCCCCCCCCCCCCC(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCCCN)=O)CCC(O)=O)=O)CCC1)=O

C38H70N6O8

739.00

[1]Almeida Scalvino S, et al. Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. Int J Cosmet Sci. 2018;40 (5) :516-524.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5247/Palmitoyl-tetrapeptide-20-SDS-MedChemExpress.pdf

Peptides

No Development Reported

MC1R; SIRT1