Panaxytriol

Panaxytriol is an active component of ginseng. Panaxytriol inhibits the nuclear translocation of NF-κB, thereby reducing the production of pro-inflammatory factors (such as TNF-α, IL-1β, IL-6) and nitric oxide (NO) induced by LPS. Panaxytriol upregulates CYP3A4 by activating the nuclear receptor PXR/CAR. Panaxytriol improves motor dysfunction in a mouse model of brain inflammation. Panaxytriol can be used in the research of neurodegenerative diseases (such as Alzheimer's disease)[2].

87005-03-6

12352211

Constitutive Androstane Receptor; Cytochrome P450; Interleukin Related; NF-κB; Pregnane X Receptor (PXR) ; TNF Receptor

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Neuroscience-Neurodegeneration

Neurological Disease

CCCCCCC[C@@H](O)[C@H](O)CC#CC#C[C@H](O)C=C

C17H26O3

278.39

[1]Yan J, et al. Panaxytriol upregulates CYP3A4 expression through the interaction between nuclear regulators and DNA response elements. J Ethnopharmacol. 2023 Jun 28;310:116398.|[2]Hiramatsu G, et al. Panaxytriol Inhibits Lipopolysaccharide-Induced Microglia Activation in Brain Inflammation in Vivo. Biol Pharm Bull. 2021;44 (7) :1024-1028.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W709413/

Natural Products

No Development Reported

CYP3A4; IL-1; IL-6; NF-κB