Pantoprazol-d8 (natrium)

Pantoprazole-d8 (BY1023-d8) sodium is a deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[4].

BY1023-d8 (sodium) ; SKF96022-d8 (sodium)

12352005

Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds; Proton Pump

Anti-infection; Apoptosis; Autophagy; Membrane Transporter/Ion Channel; Others

Cancer; Inflammation/Immunology

O=S(C1=NC2=CC=C(OC(F)F)C=C2[N-]1)C([2H])([2H])C3=NC([2H])=C([2H])C(OC([2H])([2H])[2H])=C3OC([H])([H])[2H].[Na+]

C16H6D8F2N3NaO4S

413.40

[1]Krupa J Patel, et al. Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors. Clin Cancer Res. 2013 Dec 15;19 (24) :6766-76.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.|[3]W Beil, et al. Pantoprazole: a novel H+/K (+) -ATPase inhibitor with an improved pH stability. Eur J Pharmacol. 1992 Aug 6;218 (2-3) :265-71.|[4]K Takeuchi, et al. Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: a comparative study with omeprazole and lansoprazole. J Gastroenterol Hepatol. 1999 Mar;14 (3) :251-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W739793/

Isotope-Labeled Compounds

No Development Reported