PANX1 Antilichaam

PANX1 Antibody: The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

24145

Q96RD7

NP_056183

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Inflammasomes

PANX1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1316 - Human Ovary Tissue Lysate

1 mg/mL

PANX1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PANX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

47 kDa

IgG

Two transcript variants encoding different isoforms have been found for this gene.

PANX1

Cat. No. 11-201 - Human Ovary Tissue Slide

Pannexin 1

Homo sapiens

Barbe MT, Monyer H and Bruzzone R. Cell-cell communication beyond connexins: the pannexin channels. Physiology 2006; 21:103-14.

Baranova A, Ivanov D, Petrash N, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83:706-16.

Sohl G, Maxeiner S and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 2005; 6:191-200

Bao L, Locovei S and Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 2004; 572:65-8.

PANX1 Antibody: PX1, MRS1, UNQ2529, UNQ2529/PRO6028, Pannexin-1

ELISA, WB, IF

39995064

Liquid