PARP1 Antilichaam, KO gevalideerd

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

142

P09874

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Cell Cycle, Immunology, Signal Transduction

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 100kDa, 110kDa, 125kDa

IgG

PARP1

HeLa

RAW264.7

C6

Mouse testis

Mouse brain

Poly (ADP-ribose) polymerase 1

Homo sapiens

KIF3B, PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1

WB, IHC, IF, IP, CHIP

Liquid