PATZ1 Antilichaam

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1;22) (p36.1; q12) . The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

23598

Q9HBE1

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_114440.1) .

Unconjugated

Primary Antibodies

Cancer, Transcription

Affinity purification

HT-29

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 74kDa

IgG

WB: 1:1000 - 1:4000

PATZ1

HeLa

MCF7

HL-60

HepG2

Mouse kidney

POZ (BTB) and AT hook containing zinc finger 1

Homo sapiens

PATZ1, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23

WB

Liquid