PCBP1 Antilichaam

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC) -binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

5093

Q15365

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PCBP1 (NP_006187.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

NIH/3T3

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 37kDa

IgG

PCBP1

HepG2

MCF7

Mouse liver

Rat liver

Poly (rC) binding protein 1

Homo sapiens

PCBP1, HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1

WB, IHC, IF

Liquid