PCBP2 Antilichaam - middengebied: FITC (ARP40568_T100-FITC)

Poly (rC) binding protein 2

HNRPE2, HNRNPE2, hnRNP-E2

5094

Q6IPF4

NP_005007

Human, Mouse, Rat, Cow, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the middle region of human PCBP2

PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly (rC) -binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly (rC) -binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.

FUS; HUWE1; UBC; SNRPA; SUMO2; SUMO3; CEP250; MDM2; EED; TARDBP; ADRB2; IGSF8; HMGA1; CD81; HMGA2; WDR83; SLU7; CASK; UBL4A; VCAM1; PCBP2; NOS2; ITGA4; FN1; BRCA1; PRPF40A; SF3B2; NKAP; WDR77; PAXIP1; BARD1; PPIB; EEF1A1; FBXO6; UBD; PCBP1; QKI; CDK2; COP

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

There is BioGPS gene expression data showing that PCBP2 is expressed in Jurkat

0.5 mg/ml

Cow: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

40kDa

Oh, J.H., (2005) Mamm. Genome 16 (12), 942-954

Wet Ice

366

PCBP2

PCBP2

Rabbit

Poly (rC) -binding protein 2

NM_005016

VIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQ