PCDH18 Antilichaam

PCDH18 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.

54510

Q9HCL0

NP_061908

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

PCDH18 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

PCDH18 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PCDH18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.

PCDH18

Protocadherin 18

Homo sapiens

Frank M and Kemler R. Protocadherins. Curr. Opin. Cell Biol.2002; 14:557-62.

Wolverton T and Lalande M. Identification and characterization of three members of a novel subclass of protocadherins. Genomics2001; 76:66-72.

Homayouni R, Rice DS, and Curran T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem. Biophys. Res. Commun.2001; 289:539-47.

Kubota F, Murakami T, Tajika Y, et al. Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos. Int. J. Dev. Biol.2008; 52:397-405.

PCDH18 Antibody: PCDH68L, KIAA1562, Protocadherin-18

ELISA, WB, IHC-P, IF

14589929

Liquid