PCDHGC3 Antilichaam

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

5098

Q9UN70

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 32-270 of human PCDHGC3 (NP_002579.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience, Signal Transduction

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 140kDa

IgG

WB: 1:500 - 1:2000

PCDHGC3

MCF7

SW620

Mouse liver

Mouse brain

Protocadherin gamma subfamily C, 3

Homo sapiens

PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2

WB

Liquid