PCK1 Antilichaam - middelste regio : HRP (ARP32801_P050-HRP)

Phosphoenolpyruvate carboxykinase 1 (soluble)

PCKDC, PEPCK1, PEPCKC, PEPCK-C

5105

P35558

NP_002582

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human PCK1

PCK1 is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of PCK1 can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet.This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; FBXO25; C1R; APP; CUL5; BAG6; TCP1; TCEB1; SKP1; RPS15A; RPS6; RPS3A; RPS3; RPLP0; RPL4; PSMD12; PSMD2; PSMC5; PSMC4; PSMC2; PSMC1; PSMB7; PSMB4; PSMB1; PSMA5; PSMA2; PCK1; LDHA; HSPD1; HSPA1L; DNAJA1; HLA-C; HLA-B; GNAS; GNAI1; GNA12; FASN; EP300; T

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

69kDa

Chakravarty, K., et al., (2004) J. Biol. Chem. 279 (15), 15385-15395

Wet Ice

622

PCK1

PCK1

Rabbit

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

NM_002591

NGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAS