PD-1, Cynomolgus (Biotinyleerd, HEK293, His-Avi)

PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells) . The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of PD-1 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 143 a.a., with molecular weight of 30-45 kDa.

PD-1 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi), Cynomolgus, HEK293

12352202

102123659 (Gene_ID) B0LAJ3 (L25-Q167) (Accession)

30-45 kDa

[1]Shinohara T, et al. Structure and chromosomal localization of the human PD-1 gene (PDCD1) . Genomics. 1994 Oct;23 (3) :704-6.|[2]Syn NL, et al. De-novo and acquired resistance to immune checkpoint targeting. Lancet Oncol. 2017 Dec;18 (12) :e731-e741.|[3]Francisco LM, et al. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010 Jul;236:219-42.|[4]Fife BT, et al. The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann N Y Acad Sci. 2011 Jan;1217:45-59.|[5]Latchman Y, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar;2 (3) :261-8.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins