PD-L1 (CD274) Humaan Monoklonale Antilichaam [Kloon ID: LBI13D11]

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Carrier-free (BSA/glycerol-free) A humanized monoclonal antibody against PDL1 expressed in CHO cells according to Tecentriq sequence

B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1

Homo sapiens CD274 molecule (CD274), transcript variant 1, mRNA.

29126

Q9NZQ7

Unconjugated

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

FLOW 1:50~100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CD274

https://www.ncbi.nlm.nih.gov/gene/?term=29126

https://www.uniprot.org/uniprot/Q9NZQ7