PD-L1-remmend peptide (TFA)

PD-L1 inhibitory peptide TFA is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1) . PD-L1 inhibitory peptide TFA binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide TFA is promising for research of cancers[1][2].

12352209

PD-1/PD-L1

Immunology/Inflammation

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

99.81

DMSO : 50 mg/mL (ultrasonic)

O=C(O)C(F)(F)F.OC(CN1C2=CC=CC=C2C(C[C@H]3C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N4[C@](CCC4)([H])C(N[C@H](C(N[C@H](C(N5[C@](C[C@H](C5)O)([H])C(N[C@H](C(N[C@H](C(N3)=O)CCN)=O)CC6=CNC7=CC=CC=C67)=O)=O)CC(C)C)=O)CN)=O)=O)CC(N)=O)=O)C)C)=O)CC8=CC=C(C=C8)O)=O)C(NCC(N[C@H](C(O)=O)CC#C)=O)=O)=O)CC(C)C)=O)CCCC)C)=O)CCCC)C)=O)=C1)=O.[x]

C96H135N21O23S.xC2HF3O2

1983.29 (free base)

[1]Shindo Y, et al. Anti-PD-L1 peptide improves survival in sepsis[J]. Journal of Surgical Research, 2017, 208: 33-39.|[2]Boohaker RJ, et al. Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction. Cancer Lett. 2018 Oct 10;434:11-21.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10950A/PD-L1-inhibitory-peptide-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported