PD-L1/CD274 Rabbit mAb (AMR12841N)

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1) . During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PD-L1/CD274 Rabbit mAb (APR24555N0) .

B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; CD274

29126

Q9NZQ7

Cell membrane, Endomembrane system, Single-pass type I membrane protein

ELISA 1:500 - 1:2000 WB 1:500 - 1:2000 FC 1:50 - 1:200 Inhibition1ug/ul

Liquid

Buffer: PBS with 0.09% sodium azide, 50% glycerol, pH7.4.

Calculated MW: 20kDa/33kDa Observed MW: Refer to figures

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29126

https://www.uniprot.org/uniprot/Q9NZQ7

Email for sequence