PDE12 Antilichaam - middengebied: Biotine (ARP53350 P050-Biotine)

Phosphodiesterase 12

2-PDE, 2'-PDE

201626

Q6L8Q7

NP_808881

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human 2'-PDE

2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) . Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

SUMO2; SUMO1; UBC; NEDD8; DCTPP1; NPLOC4; UBQLN2; EHD1; WDR4; PDLIM5; SAE1; UBA2; CUL5; XPNPEP1; STAT6; RAD23B; PGGT1B; DNAJB1; ADSL; APEX2; COPS5; CUL3; UBL4A

Biotin

Polyclonal Antibody

WB

Affinity Purified

PDE12 is supported by BioGPS gene expression data to be expressed in OVCAR3

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

67kDa

Kubota, K., (2004) J. Biol. Chem. 279 (36), 37832-37841

Wet Ice

609

PDE12

PDE12

Rabbit

2',5'-phosphodiesterase 12

NM_177966

CLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKW