PDGF-AA Recombinant eiwit

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α -granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β . PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids) .

5154

P04085

NP_002598.4

Recombinant Proteins

E. coli

Cancer, Cell Cycle, Growth Factors, Immunology, Obesity, Signal Transduction

Room Temp

The lyophilized PDGF-AA recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PDGF-AA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PDGF-AA recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Platelet-derived growth factor alpha polypeptide

Homo sapiens

PDGF1, PDGF-A, PDGF1, Platelet-derived growth factor subunit A, PDGF-1, PDGF subunit A

Human

77695917

Lyophilized