PDGF-B Antilichaam

PDGF-B Antibody: The platelet-derived growth factor beta (PDGF-B) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB) . Mutations in this gene are associated with meningioma , and reciprocal translocations between chromosomes 22 and 7, at sites where the PDGF-B gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans.

5155

P01127

NP_002599

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

PDGF-B Antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Sheep: (100%)

PDGF-B Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PDGF-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 27 kDa

IgG

PDGFB

Cat. No. 10-201 - Human Liver Tissue Slide

Platelet-derived growth factor beta polypeptid

Homo sapiens

Johnsson A, Heldin CH, Wasteson A, et al. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J. 1984; 3:921-8.

Fredriksson L, Li H, and Eriksson U. The PDGF family: four gene products for five dimeric isoforms. Cyto. Growth Factor Rev. 2004; 15:197-204.

Maxwell M, Galanopoulos T, Hedley-Whyte ET, et al. Human meningiomas co-express platelet-derived growth factor) PDGF) and PDGF-receptor genes and their protein products. Int. J. Cancer 1990; 46:16-21.

Simon MP, Navarro M, Roux D, et al. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t (17;22) (q22; q13.1) in Dermatofibrosarcoma protuberans (DP) . Oncogene 2001; 20:2965-75.

PDGF-B Antibody: SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2, SIS, Platelet-derived growth factor subunit B, PDGF subunit B

ELISA, WB, IF

4505681

Liquid