PDK1 Antilichaam - middengebied HRP (ARP31776_P050-HRP)

Pyruvate dehydrogenase kinase, isozyme 1

5163

Q15118

NP_002601

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the middle region of human PDK1

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

EGFR; PDK1; KAT2B; USP4; UBC; MYC; XRCC6; SGK1; DLAT; RPS6KB1; PDK2; PDHA1; YWHAQ; RPTOR; RALGDS; PKN2; PKN1; MTOR; AKT1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

PDK1 is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 86%; Dog: 79%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 86%; Yeast: 90%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Ohba, T., (2008) Biochem. Biophys. Res. Commun. 369 (2), 376-381

Wet Ice

436

PDK1

PDK1

Rabbit

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

NM_002610

ATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMY