PEA-15 (fosfo Ser104) Antilichaam

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

8682

Q15121

NP_003759.1

Human, Mouse, Rat

PEA-15 (phospho Ser104) antibody was raised against a peptide sequence around phosphorylation site of Serine 104 (I-P-S (p) -A-K) derived from Human PEA-15.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

19 kDa

IgG

The antibody detects endogenous levels of PEA-15 only when phosphorylated at serine 104.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

PEA15

Phosphoprotein enriched in astrocytes 15

Homo sapiens

Estelles A., J. Biol. Chem. 271:14800-14806 (1996) .

Condorelli G., EMBO J. 17:3858-3866 (1998) .

Wolford J.K., Gene 241:143-148 (2000) .

PE15, PEA15, PED

WB, IHC

32470612

Liquid