PEAR1 Antilichaam

PEAR1 Antibody: Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.

375033

Q5VY43

NP_001073940

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

PEAR1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1465 - Rat Kidney Tissue Lysate

1 mg/mL

PEAR1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PEAR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PEAR1

Cat. No. 10-401 - Human Kidney Tissue Slide

Platelet endothelial aggregation receptor 1

Homo sapiens

Nanda N, Bao M, Lin H, et al. Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in the platelet contact-induced activation. J. Biol. Chem.2005; 280:24680-9.

Herrera-Galeano JE, Becker DM, Wilson AF, et al. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabili. Arterioscler. Thromb. Vasc. Biol.2008; 28:1484-90.

PEAR1 Antibody: JEDI, MEGF12, Platelet endothelial aggregation receptor 1, Multiple epidermal growth factor-like domains protein 12, hPEAR1

ELISA, WB, IHC-P, IF

122937343

Liquid