PECAM-1 (fosfo-Tyr713) Antilichaam

Induces susceptibility to atherosclerosis By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte.

5175

P16284

NP_000433.4

Human, Mouse

PECAM-1 (phospho Tyr713) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine 713 (T-V-Y (p) -S-E) derived from Human PECAM-1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

82, 150 kDa

IgG

The antibody detects endogenous level of PECAM-1 only when phosphorylated at tyrosine 713.

Western Blot: 1:500~1:1000

PECAM1

Platelet/endothelial cell adhesion molecule 1

Homo sapiens

Garnacho C, et al. (2008) Blood 111, 3024-33. Udell CM, et al. (2006) J Biol Chem 281, 20949-57 . O'Brien CD, Cao G, Makrigiannakis A, DeLisser HM (2004) Am J Physiol Cell Physiol 287, C1103-13.

CD31, CD31 antigen, EndoCAM, PEC1, PECAM

WB

313760624

Liquid