PEDF Aanbevolen eiwit

PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR) . PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.

5176

P36955

NP_002606.3

Recombinant Proteins

E. coli

Cancer, Immunology, Innate Immunity, Neuroscience, Obesity, Signal Transduction, Stem Cell

Room Temp

The lyophilized PEDF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted PEDF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing PEDF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Homo sapiens

OI6, OI12, PEDF, EPC-1, PIG35, Pigment epithelium-derived factor, Cell proliferation-inducing gene 35 protein

Human

39725934

Lyophilized