Pefloxacine (standaard)

Pefloxacin (Standard) (Pefloxacinium (Standard) ) is the analytical standard of Pefloxacin. This product is intended for research and analytical applications. Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies[1][2][3][4][5][6][7][8][9].

70458-92-3

Pefloxacinium (Standard)

12352005

Antibiotic; Bacterial; DNA/RNA Synthesis; Parasite; Reference Standards; Topoisomerase

Anti-infection; Cell Cycle/DNA Damage; Others

Infection; Inflammation/Immunology

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCN(C)CC3)=C2)C1=O)O

C17H20FN3O3

333.36

[1]Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61 (3) :377-92.|[2]Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29 (6) :1073-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0147R/

Reference Standards