PEK/PERK (fosfo Thr982) Antilichaam

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)

9451

Q9NZJ5

NP_004827.4

Human, Mouse

PEK/PERK (phospho Thr982) antibody was raised against a peptide sequence around phosphorylation site of threonine 981 (A-R-H (p) -T-G) derived from Human PEK/PERK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

125 kDa

IgG

The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3

Homo sapiens

Shi Y., An J., J. Biol. Chem. 274:5723-5730 (1999) .

Sood R., Biochem. J. 346:281-293 (2000) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

E2AK3, PERK, PEK, EIF2AK3

IHC

296439367

Liquid