Pep2-8 analoog 18

Pep2-8 analogue 18 is a high affinity PCSK9 (KD = 6 nM) inhibitory peptide. Pep2-8 analogue 18 restores LDL uptake in HepG2 cells (EC50 = 175 nM) . Pep2-8 analogue 18 has good cellular safety. Pep2-8 analogue 18 can be used for research on cardiovascular conditions[1].

12352209

PCSK9

Metabolic Enzyme/Protease

Cancer-programmed cell death

Cancer

O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCCNC5=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CC(C)C)C(N[C@@H](C5)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C

C124H190N32O25

2529.03

[1]Bourbiaux K, et al. Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9. J Med Chem. 2021 Aug 12;64 (15) :10834-10848.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11216/

Peptides

No Development Reported