Pep2-SVKI

Pep2-SVKI is a selective peptide inhibitor. pep2-SVKI inhibits the binding of AMPA-type glutamate receptor (GluA2) (C-terminal PDZ site) to glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1) . pep2-SVKI increases the amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD) . pep2-SVKI can be used to study neurological diseases[1][2][3][4].

328944-75-8

12352209

IGluR

Membrane Transporter/Ion Channel; Neuronal Signaling

Neurological Disease

O=C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N

C60H93N13O18

1284.46

[1]Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8 (6) :768-75.|[2]Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28 (3) :873-86.|[3]Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50 (3) :286-96.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P1056/

Peptides

Phase 1