PepW

PepW is a potent antimicrobial peptide targeting the capsule of multidrug-resistant Klebsiella pneumoniae (MIC=2-8 μM) . PepW achieves bactericidal activity via capsule polysaccharide aggregation and structural disruption. PepW is promising for research of infectious diseases caused by Gram-negative bacteria (e.g., pneumonia, sepsis) [1].

12352209

Bacterial

Anti-infection

COVID-19-immunoregulation

Infection

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C)C(N[C@@H](CCN)C(N[C@@H](CC5=CC=C(C=C5)O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCN)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCN)C(N[C@@H](CCN)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CC9=CC=C(C=C9)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%10=CNC%11=CC=CC=C%10%11)N

C114H150N26O21

2220.57

[1]Fleeman RM, et al. Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae. Proc Natl Acad Sci U S A. 2020 Nov 3;117 (44) :27620-27626.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11100/

Peptides

No Development Reported