Perezone

Perezone is a sesquiterpenoid benzoquinone found in the roots of Acourtia species. Perezone inhibits the activity of leukemia cell line K-562 and human glioma cell line U-251 (IC50: 6.83 μM) . Perezone increases the expression of caspase 3, 8, and 9 genes associated with apoptosis. Perezone has antioxidant and anti-inflammatory activities[1][2][3][4][5].

3600-95-1

12352211

Apoptosis

Apoptosis

Cancer; Inflammation/Immunology

C/C(C)=C\CC[C@H](C1=C(C(C(C)=CC1=O)=O)O)C

C15H20O3

248.32

[1]Gómez-Serrano G, et al. Time-dependent perezone production in different culture systems of Acourtia cordata[J]. Central European Journal of Biology, 2012, 7: 507-518.|[2]Escobedo-González R G, et al. Characterization and comparison of perezone with some analogues. Experimental and theoretical study[J]. Journal of Molecular Structure, 2015, 1097: 98-105.|[3]Estévez-Carmona MM, et al. Perezone and its phenyl glycine derivative induce cytotoxicity via caspases on human glial cancer cells. Nat Prod Res. 2024 Jun;38 (11) :1823-1833. |[4]Concepción Lozada M, et al. Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone. Bioorg Med Chem. 2012 Sep 1;20 (17) :5077-84.|[5]Martínez J, et al. Computational Characterization of Perezone, Isoperezone and their Sulfur‐Derivatives: Anti‐inflammatory Activity[J]. ChemistrySelect, 2019, 4 (45) : 13333-13346.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15582/

Natural Products

No Development Reported