Perforine-antilichaam

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

5551

P14222

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin (NP_001076585.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Immunology, Innate Immunity

Affinity purification

Mouse thymus

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 70kDa

IgG

PRF1

Mouse kidney

Perforin 1 (pore forming protein)

Homo sapiens

PFP, Perforin-1, Cytolysin, P1, PFP, FLH2, PFN1, HPLH2

WB, IHC, IF

Liquid