Perifosine (standaard)

Perifosine (Standard) is the analytical standard of Perifosine. This product is intended for research and analytical applications. Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC50s of 0.6-8.9 μM.

157716-52-4

12352100

Akt; Apoptosis; Autophagy; Reference Standards

Apoptosis; Autophagy; Others; PI3K/Akt/mTOR

Cancer

[O-]P(OC1CC[N+](C)(CC1)C)(OCCCCCCCCCCCCCCCCCC)=O

C25H52NO4P

461.66

[1]Momota H, et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res, 2005, 65 (16), 7429-7435.|[2]Vyomesh Patel, et al. Perifosine, a novel alkylphospholipid, induces p21 (WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res, 2002, 62 (5), 14|[3]Chen L, et al. Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia. 2012 Nov;53 (11) :2026-33.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-50909R/

Reference Standards