Periplogenine (standaard)

Periplogenin (Standard) is the analytical standard of Periplogenin. Periplogenin is an orally active cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis[1][2][3].

514-39-6

12352005

Caspase; Interleukin Related; Necroptosis; NOD-like Receptor (NLR) ; Pyroptosis; Reactive Oxygen Species (ROS) ; Reference Standards

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Cancer; Inflammation/Immunology

O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C4=CC(OC4)=O)CC2)C)([H])[C@@]5([C@@](O)(C[C@@H](O)CC5)CC3)C

C23H34O5

390.51

[1]Zhang WJ, et al. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016 Apr 1;105:66-79.|[2]Ma X, et al. Periplogenin inhibits pyroptosis of fibroblastic synoviocytes in rheumatoid arthritis through the NLRP3/Caspase-1/GSDMD signaling pathway. Int Immunopharmacol. 2024 May 30;133:112041.|[3]Zhang X, et al. The natural compound periplogenin suppresses the growth of prostate carcinoma cells by directly targeting ATP1A1. Sci Rep. 2024 Sep 3;14 (1) :20509.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N2414R/

Reference Standards

Caspase 1; IL-1; NLRP3